Reactome | Inactive RAFs bind YWHAB

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10616047
displayName	Inactive RAFs bind YWHAB
eventOf	[Pathway:R-DRE-5673000] RAF activation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Danio rerio
inferredFrom	[Reaction:R-HSA-5672951] Inactive RAFs bind YWHAB - Homo sapiens
input	[DefinedSet:R-DRE-5672708] inactive RAFs [cytosol] [Complex:R-DRE-2028645] YWHAB dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Inactive RAFs bind YWHAB
output	[Complex:R-DRE-5672707] inactive RAFs:YWHAB dimer [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5672951
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-5673000] RAF activation
(precedingEvent)	[Reaction:R-DRE-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
(inferredTo)	[Reaction:R-HSA-5672951] Inactive RAFs bind YWHAB

Cite Us!