Reactome | Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

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Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650404
displayName	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
eventOf	[Pathway:R-DRE-9006335] Signaling by Erythropoietin - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262292] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-9027272] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 - Danio rerio [Reaction:R-DRE-9012657] EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K - Danio rerio [Reaction:R-DRE-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Danio rerio
inferredFrom	[Pathway:R-HSA-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-9027276
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9006335] Signaling by Erythropoietin
(inferredTo)	[Pathway:R-HSA-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

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