Reactome | EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2

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EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 Show undefined attributes

catalystActivity	[CatalystActivity:10638341] protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10638343
displayName	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
eventOf	[Pathway:R-DRE-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9012657] EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K - Danio rerio
inferredFrom	[Reaction:R-HSA-9027272] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DRE-9006301] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DRE-9027242] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9027272
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9027276] Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
(precedingEvent)	[Reaction:R-DRE-9012657] EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
(inferredTo)	[Reaction:R-HSA-9027272] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2

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