Reactome | Transcriptional regulation by RUNX2

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Transcriptional regulation by RUNX2 Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650332
displayName	Transcriptional regulation by RUNX2
eventOf	[Pathway:R-DRE-212436] Generic Transcription Pathway - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DRE-8939902] Regulation of RUNX2 expression and activity - Danio rerio [Reaction:R-DRE-8985343] RUNX2 binds SOX9 - Danio rerio [Reaction:R-DRE-9008412] CDK4 phosphorylates RUNX2 - Danio rerio [Reaction:R-DRE-9009282] CDK1 phosphorylates RUNX2 - Danio rerio [Pathway:R-DRE-8941326] RUNX2 regulates bone development - Danio rerio [Reaction:R-DRE-9008822] PPM1D dephosphorylates RUNX2 - Danio rerio
inferredFrom	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Transcriptional regulation by RUNX2
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-8878166
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-212436] Generic Transcription Pathway
(hasEncapsulatedEvent)	[Pathway:R-DRE-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression [Pathway:R-DRE-8878171] Transcriptional regulation by RUNX1
(inferredTo)	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2

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