Reactome | PC carboxylates PYR to OA

Schema > Reaction > Entries

PC carboxylates PYR to OA Show undefined attributes

catalystActivity	[CatalystActivity:10561297] pyruvate carboxylase activity of PC tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10561299
displayName	PC carboxylates PYR to OA
eventOf	[Pathway:R-DRE-70263] Gluconeogenesis - Danio rerio [Pathway:R-DRE-70268] Pyruvate metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9012016] FAHD1 dimer hydrolyses OA to PYR - Danio rerio [Reaction:R-DRE-372819] PCK2 phosphorylates OA to yield PEP - Danio rerio [Reaction:R-DRE-70613] GOT2 transaminates OA and L-Glu - Danio rerio [Reaction:R-DRE-70975] CS acetylates OA to citrate - Danio rerio
goBiologicalProcess	[GO_BiologicalProcess:15002] gluconeogenesis
inferredFrom	[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-29896] HCO3- [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PC carboxylates PYR to OA PC catalyzes the carboxylation of PYR to form OA ATP + hydrogencarbonate + pyruvate => ADP + H(+) + oxaloacetate + phosphate
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-9012016] FAHD1 dimer hydrolyses OA to PYR - Danio rerio [Reaction:R-DRE-9012268] ME2 tetramer decarboxylates MAL to PYR - Danio rerio [Reaction:R-DRE-9012349] ME3 tetramer decarboxylates MAL to PYR - Danio rerio [Reaction:R-DRE-9861667] DLAT trimer transfers acetyl to CoA - Danio rerio
regulatedBy	[Requirement:R-GGA-354223] Requirement by 'Ac-CoA [mitochondrial matrix]' [NegativeRegulation:9986299] Negative regulation by '2OG [mitochondrial matrix]' [NegativeRegulation:9986300] Negative regulation by 'L-Glu [mitochondrial matrix]' [NegativeRegulation:9986301] Negative regulation by 'MAL [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-70501
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-70268] Pyruvate metabolism [Pathway:R-DRE-70263] Gluconeogenesis
(precedingEvent)	[Reaction:R-DRE-70975] CS acetylates OA to citrate [Reaction:R-DRE-372819] PCK2 phosphorylates OA to yield PEP [Reaction:R-DRE-9012016] FAHD1 dimer hydrolyses OA to PYR [Reaction:R-DRE-70613] GOT2 transaminates OA and L-Glu
(inferredTo)	[Reaction:R-HSA-70501] PC carboxylates PYR to OA