Reactome | DLAT trimer transfers acetyl to CoA

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DLAT trimer transfers acetyl to CoA Show undefined attributes

catalystActivity	[CatalystActivity:10645064] dihydrolipoyllysine-residue acetyltransferase activity of PDH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10645066
displayName	DLAT trimer transfers acetyl to CoA
eventOf	[Pathway:R-DRE-9861559] PDH complex synthesizes acetyl-CoA from PYR - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9861616] DLD dimer dehydrogenates dihydrolipoyl - Danio rerio [Reaction:R-DRE-203946] PDK isozymes phosphorylate PDHC subunit E1 - Danio rerio [Reaction:R-DRE-70501] PC carboxylates PYR to OA - Danio rerio
inferredFrom	[Reaction:R-HSA-9861667] DLAT trimer transfers acetyl to CoA - Homo sapiens
input	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [EntityWithAccessionedSequence:R-DRE-9861594] dlat [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	DLAT trimer transfers acetyl to CoA
output	[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [EntityWithAccessionedSequence:R-DRE-9861664] dlat [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Danio rerio [Reaction:R-DRE-204169] PDP1,2 dephosphorylate p-lipo-PDH - Danio rerio
regulatedBy	[NegativeRegulation:10645067] Negative regulation by 'DLAT [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9861667
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9861559] PDH complex synthesizes acetyl-CoA from PYR
(precedingEvent)	[Reaction:R-DRE-70501] PC carboxylates PYR to OA [Reaction:R-DRE-203946] PDK isozymes phosphorylate PDHC subunit E1 [Reaction:R-DRE-9861616] DLD dimer dehydrogenates dihydrolipoyl
(inferredTo)	[Reaction:R-HSA-9861667] DLAT trimer transfers acetyl to CoA