Reactome | Assembly of the pre-replicative complex

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Assembly of the pre-replicative complex Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10647422
displayName	Assembly of the pre-replicative complex
eventOf	[Pathway:R-DRE-69002] DNA Replication Pre-Initiation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-DRE-68962] Activation of the pre-replicative complex - Danio rerio
goBiologicalProcess	[GO_BiologicalProcess:4341223] pre-replicative complex assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-DRE-68616] Assembly of the ORC complex at the origin of replication - Danio rerio [Pathway:R-DRE-68689] CDC6 association with the ORC:origin complex - Danio rerio [Reaction:R-DRE-9757256] MCM3 binds MCM5 - Danio rerio [Reaction:R-DRE-9757257] MCM4, MCM6 and MCM7 form a heterotrimer - Danio rerio [Reaction:R-DRE-9757258] MCM2 binds MCM4:MCM6:MCM7 heterotrimer - Danio rerio [Reaction:R-DRE-9749253] Formation of MCM2-7 complex - Danio rerio [BlackBoxEvent:R-DRE-68712] The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 - Danio rerio [BlackBoxEvent:R-DRE-68825] Ubiquitinated geminin is degraded by the proteasome - Danio rerio
inferredFrom	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Assembly of the pre-replicative complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-68867
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Pathway:R-DRE-68962] Activation of the pre-replicative complex
(hasEvent)	[Pathway:R-DRE-69002] DNA Replication Pre-Initiation
(inferredTo)	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex