Reactome | Assembly of the ORC complex at the origin of replication

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Assembly of the ORC complex at the origin of replication Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10647420
displayName	Assembly of the ORC complex at the origin of replication
eventOf	[Pathway:R-DRE-68867] Assembly of the pre-replicative complex - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-9734670] ORC6 binds KPNA1 or KPNA6 - Danio rerio [BlackBoxEvent:R-DRE-9734687] ORC6 is phosphorylated on T195 - Danio rerio [BlackBoxEvent:R-DRE-9734713] ORC6 translocates to the nucleus - Danio rerio [BlackBoxEvent:R-DRE-9734730] ORC1 translocates to the nucleus - Danio rerio [Reaction:R-DRE-9749197] ORC1 binds to H4K20me2 - Danio rerio [Reaction:R-DRE-68595] ORC2 binds ORC3 - Danio rerio [Reaction:R-DRE-68603] ORC5 binds ORC2:ORC3 - Danio rerio [Reaction:R-DRE-68610] Formation of ORC(2-5) complex - Danio rerio [Reaction:R-DRE-68611] Formation of ORC(1-5) complex - Danio rerio [Reaction:R-DRE-68615] Formation of ORC(1-6) complex - Danio rerio
inferredFrom	[Pathway:R-HSA-68616] Assembly of the ORC complex at the origin of replication - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Assembly of the ORC complex at the origin of replication
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-68616
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-68867] Assembly of the pre-replicative complex
(inferredTo)	[Pathway:R-HSA-68616] Assembly of the ORC complex at the origin of replication

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