Reactome | 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane

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4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10578060] cholesterol transfer activity of 4xPALM-C-p-2S-ABCA1 tetramer:APOA1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10578062
displayName	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane
eventOf	[Pathway:R-DRE-8963896] HDL assembly - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-349657] pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Danio rerio [Reaction:R-DRE-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Danio rerio
inferredFrom	[Reaction:R-HSA-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-216762] CHOL [transport vesicle membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane ABCA1-mediated transport of intracellular cholesterol to the cell surface
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-171095] CHOL [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-DRE-216727] 4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 - Danio rerio [Reaction:R-DRE-6813720] NCEH1 hydrolyzes cholesterol esters - Danio rerio [Reaction:R-DRE-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-216723
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8963896] HDL assembly
(precedingEvent)	[Reaction:R-DRE-349657] pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle [Reaction:R-DRE-216756] Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
(inferredTo)	[Reaction:R-HSA-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane

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