Reactome | CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter

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CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter Show undefined attributes

catalystActivity	[CatalystActivity:10628188] protein serine/threonine kinase activity of RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10628190
displayName	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter
eventOf	[Pathway:R-DRE-6807505] RNA polymerase II transcribes snRNA genes - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6810233] CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter - Homo sapiens
input	14 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-DRE-6810219] RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter
output	14 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-DRE-6810221] RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm]
precedingEvent	[Reaction:R-DRE-6810238] RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6810233
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-6807505] RNA polymerase II transcribes snRNA genes
(inferredTo)	[Reaction:R-HSA-6810233] CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter

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