Reactome | RA biosynthesis pathway

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RA biosynthesis pathway Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648794
displayName	RA biosynthesis pathway
eventOf	[Pathway:R-DRE-5362517] Signaling by Retinoic Acid - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-5362564] ADH1A,1C,4 oxidise atROL to atRAL in vitro - Danio rerio [Reaction:R-DRE-5362518] RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL - Danio rerio [Reaction:R-DRE-5419165] RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL - Danio rerio [Reaction:R-DRE-5362522] ALDHs oxidise atRAL to atRA - Danio rerio [Reaction:R-DRE-5362721] RDH5,RDH11 oxidise 11cROL to 11cRAL - Danio rerio [Reaction:R-DRE-5622134] CRABP1 binds atRA - Danio rerio [Reaction:R-DRE-5362525] CYP26A1,B1,C1 4-hydroxylate atRA - Danio rerio [Reaction:R-DRE-5696101] ALDH8A1 oxidises 9cRAL to 9cRA - Danio rerio [Reaction:R-DRE-211923] CYP26C1 4-hydroxylates 9cRA - Danio rerio
inferredFrom	[Pathway:R-HSA-5365859] RA biosynthesis pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RA biosynthesis pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-5365859
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5362517] Signaling by Retinoic Acid
(inferredTo)	[Pathway:R-HSA-5365859] RA biosynthesis pathway

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