Reactome | ALDHs oxidise atRAL to atRA

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ALDHs oxidise atRAL to atRA Show undefined attributes

catalystActivity	[CatalystActivity:10612146] retinal dehydrogenase (NAD+) activity of ALDH1A1,2,3 tetramers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10612148
displayName	ALDHs oxidise atRAL to atRA
eventOf	[Pathway:R-DRE-5365859] RA biosynthesis pathway - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5334827] SUMO-CRABP2 binds atRA - Danio rerio [Reaction:R-DRE-5622134] CRABP1 binds atRA - Danio rerio [Reaction:R-DRE-5622129] FABP5 binds atRA - Danio rerio
inferredFrom	[Reaction:R-HSA-5362522] ALDHs oxidise atRAL to atRA - Homo sapiens
input	[SimpleEntity:R-ALL-975622] atRAL [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALDHs oxidise atRAL to atRA
output	[SimpleEntity:R-ALL-5334816] atRA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-DRE-5362564] ADH1A,1C,4 oxidise atROL to atRAL in vitro - Danio rerio [Reaction:R-DRE-5362518] RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5362522
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DRE-5334827] SUMO-CRABP2 binds atRA [Reaction:R-DRE-5622134] CRABP1 binds atRA [Reaction:R-DRE-5622129] FABP5 binds atRA
(hasEvent)	[Pathway:R-DRE-5365859] RA biosynthesis pathway
(inferredTo)	[Reaction:R-HSA-5362522] ALDHs oxidise atRAL to atRA