Reactome | NAPRT1 dimer transfers PRIB to NCA to form NAMN

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NAPRT1 dimer transfers PRIB to NCA to form NAMN Show undefined attributes

catalystActivity	[CatalystActivity:10574291] nicotinate phosphoribosyltransferase activity of NAPRT1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10574293
displayName	NAPRT1 dimer transfers PRIB to NCA to form NAMN
eventOf	[Pathway:R-DRE-196807] Nicotinate metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259346] NAD+ biosynthetic process via the salvage pathway
inferredFrom	[Reaction:R-HSA-197186] NAPRT1 dimer transfers PRIB to NCA to form NAMN - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-197230] NCA [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NAPRT1 dimer transfers PRIB to NCA to form NAMN nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O => nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN)
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-8869359] NAMN [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-DRE-8869603] SLC22A13 exchanges extracellular NCA for cytosolic urate - Danio rerio [Reaction:R-DRE-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Danio rerio
regulatedBy	[Requirement:R-HSA-2509853] Requirement by 'Mg2+ [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-197186
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-197186] NAPRT1 dimer transfers PRIB to NCA to form NAMN

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