Reactome | pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

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pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10578483
displayName	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
eventOf	[Pathway:R-DRE-8963896] HDL assembly - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-349657] pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Homo sapiens
input	9 × [SimpleEntity:R-ALL-171095] CHOL [plasma membrane] 22 × [SimpleEntity:R-ALL-171142] PL [plasma membrane] [Complex:R-DRE-349645] pre-beta HDL [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
output	[Complex:R-DRE-216752] discoidal HDL [extracellular region]
precedingEvent	[Reaction:R-DRE-216723] 4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane - Danio rerio [Reaction:R-DRE-216757] 4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-349657
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8963896] HDL assembly
(inferredTo)	[Reaction:R-HSA-349657] pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

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