Reactome | Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

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Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10647826
displayName	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
eventOf	[Pathway:R-DRE-2142753] Arachidonate metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9974] prostanoid biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-2309779] PTGS2 dimer binds PTGS2 inhibitors - Danio rerio [Reaction:R-DRE-9716836] PTGS2 dimer binds PTGS inhibitors - Danio rerio [Reaction:R-DRE-2314678] ASA- acetylates PTGS1 - Danio rerio [Reaction:R-DRE-2314686] ASA- acetylates PTGS2 - Danio rerio [Reaction:R-DRE-140355] Arachidonate is oxidised to PGG2 by PTGS1 - Danio rerio [Reaction:R-DRE-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Danio rerio [Reaction:R-DRE-9716838] PTGS1,2 dimers bind PTGS Inhibitors - Danio rerio [Reaction:R-DRE-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Danio rerio [Reaction:R-DRE-140359] PGG2 is reduced to PGH2 by PTGS1 - Danio rerio [Reaction:R-DRE-2309773] PGG2 is reduced to PGH2 by PTGS2 - Danio rerio [Reaction:R-DRE-2161660] PGH2 is isomerised to PGE2 by PTGES - Danio rerio [Reaction:R-DRE-265295] Prostaglandin E synthase isomerizes PGH2 to PGE2 - Danio rerio [Reaction:R-DRE-2161651] PGE2 is converted to PGF2a by CBR1 - Danio rerio [Reaction:R-DRE-2161620] PGH2 is isomerised to PGD2 by PTGDS - Danio rerio [Reaction:R-DRE-76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 - Danio rerio [Reaction:R-DRE-76500] TBXAS1 isomerises PGH2 to TXA2 - Danio rerio [Reaction:R-DRE-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1 - Danio rerio
inferredFrom	[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-2162123
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2142753] Arachidonate metabolism
(hasEncapsulatedEvent)	[Pathway:R-DRE-9753281] Paracetamol ADME [Pathway:R-DRE-9749641] Aspirin ADME
(inferredTo)	[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

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