Reactome | PGG2 is reduced to PGH2 by PTGS2

Schema > Reaction > Entries

PGG2 is reduced to PGH2 by PTGS2 Show undefined attributes

catalystActivity	[CatalystActivity:10603491] peroxidase activity of PTGS2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10603495
displayName	PGG2 is reduced to PGH2 by PTGS2
eventOf	[Pathway:R-DRE-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1 - Danio rerio [Reaction:R-DRE-2161620] PGH2 is isomerised to PGD2 by PTGDS - Danio rerio [Reaction:R-DRE-76500] TBXAS1 isomerises PGH2 to TXA2 - Danio rerio [Reaction:R-DRE-76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 - Danio rerio
inferredFrom	[Reaction:R-HSA-2309773] PGG2 is reduced to PGH2 by PTGS2 - Homo sapiens
input	[SimpleEntity:R-ALL-9915557] hydrogen donor [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-140357] PGG2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	PGG2 is reduced to PGH2 by PTGS2 AH2 + prostaglandin G2 = A + H2O + prostaglandin H2 Peroxidative reduction of PGG2 to PGH2
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-9915551] hydrogen acceptor [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-30138] PGH2 [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-DRE-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Danio rerio
regulatedBy	[PositiveRegulation:R-HSA-5362144] Positive regulation by 'MNA [cytosol]' [NegativeRegulation:10603496] Negative regulation by 'PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2309773
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
(precedingEvent)	[Reaction:R-DRE-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1 [Reaction:R-DRE-2161620] PGH2 is isomerised to PGD2 by PTGDS [Reaction:R-DRE-76500] TBXAS1 isomerises PGH2 to TXA2 [Reaction:R-DRE-76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2
(inferredTo)	[Reaction:R-HSA-2309773] PGG2 is reduced to PGH2 by PTGS2