Reactome | Aspirin ADME

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Aspirin ADME Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:984] extracellular region [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650552
displayName	Aspirin ADME
eventOf	[TopLevelPathway:R-DRE-9748784] Drug ADME - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol - Danio rerio [Reaction:R-DRE-9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells - Danio rerio [Reaction:R-DRE-9749647] CES2 hydrolyzes ASA- - Danio rerio [Reaction:R-DRE-9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes - Danio rerio [Reaction:R-DRE-9749792] CES1,CES2 hydrolyze ASA- to ST - Danio rerio [Reaction:R-DRE-9749986] CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA - Danio rerio [Reaction:R-DRE-9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA - Danio rerio [Reaction:R-DRE-9749971] ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA - Danio rerio [Reaction:R-DRE-9750656] ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells - Danio rerio
inferredFrom	[Pathway:R-HSA-9749641] Aspirin ADME - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Aspirin ADME
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-9749641
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-DRE-9748784] Drug ADME
(inferredTo)	[Pathway:R-HSA-9749641] Aspirin ADME
(hasEncapsulatedEvent)	[Pathway:R-DRE-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

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