Reactome | Signaling by NOTCH1

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649596
displayName	Signaling by NOTCH1
eventOf	[Pathway:R-DRE-157118] Signaling by NOTCH - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DRE-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Danio rerio
inferredFrom	[Pathway:R-HSA-1980143] Signaling by NOTCH1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Signaling by NOTCH1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-1980143
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-157118] Signaling by NOTCH
(hasEncapsulatedEvent)	[Pathway:R-DRE-8878159] Transcriptional regulation by RUNX3 [Pathway:R-DRE-8878171] Transcriptional regulation by RUNX1 [Pathway:R-DRE-8878166] Transcriptional regulation by RUNX2 [Pathway:R-DRE-1980145] Signaling by NOTCH2 [Pathway:R-DRE-1912422] Pre-NOTCH Expression and Processing
(inferredTo)	[Pathway:R-HSA-1980143] Signaling by NOTCH1