Reactome | Signaling by NOTCH

Schema > Pathway > Entries

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649598
displayName	Signaling by NOTCH
eventOf	[TopLevelPathway:R-DRE-162582] Signal Transduction - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DRE-1912422] Pre-NOTCH Expression and Processing - Danio rerio [Pathway:R-DRE-1980143] Signaling by NOTCH1 - Danio rerio [Pathway:R-DRE-1980145] Signaling by NOTCH2 - Danio rerio [Pathway:R-DRE-9013694] Signaling by NOTCH4 - Danio rerio
inferredFrom	[Pathway:R-HSA-157118] Signaling by NOTCH - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Signaling by NOTCH NOTCH Signaling Pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-157118
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[TopLevelPathway:R-DRE-162582] Signal Transduction
(hasEncapsulatedEvent)	[Pathway:R-DRE-8986944] Transcriptional Regulation by MECP2
(inferredTo)	[Pathway:R-HSA-157118] Signaling by NOTCH

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