Reactome | cdkn1ba [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10560847] cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DRE-187926] Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] - Danio rerio [Complex:R-DRE-68376] Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] - Danio rerio
consumedByEvent	[Reaction:R-DRE-9632868] CDKN1B is phosphorylated in response to estrogen - Danio rerio [Reaction:R-DRE-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Danio rerio [Reaction:R-DRE-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10560790
displayName	cdkn1ba [nucleoplasm]
endCoordinate	198
inDisease	false
inferredFrom	[DefinedSet:R-HSA-182558] CDKN1A,CDKN1B [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-182563] CDKN1B [nucleoplasm] - Homo sapiens
maxDepth	1
memberOf	[CandidateSet:R-DRE-8948131] CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] - Danio rerio
name	cdkn1ba CDKN1B Q5RGY9
producedByEvent	[Reaction:R-DRE-187506] Translocation of p27 to the nucleoplasm - Danio rerio
referenceEntity	[ReferenceGeneProduct:uniprot:Q5RGY9] UniProt:Q5RGY9
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:68323] Danio rerio
stId	R-DRE-182563
startCoordinate	1

(input)	[Reaction:R-DRE-9632868] CDKN1B is phosphorylated in response to estrogen [Reaction:R-DRE-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 [Reaction:R-DRE-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21
(hasComponent)	[Complex:R-DRE-187926] Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] [Complex:R-DRE-68376] Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] [Complex:R-DRE-187516] Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm]
(physicalEntity)	[CatalystActivity:10560847] cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]
(output)	[Reaction:R-DRE-187506] Translocation of p27 to the nucleoplasm
(inferredTo)	[DefinedSet:R-HSA-182558] CDKN1A,CDKN1B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-182563] CDKN1B [nucleoplasm]
(hasMember)	[CandidateSet:R-DRE-8948131] CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm]