Reactome | betaKlotho-mediated ligand binding

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649466
displayName	betaKlotho-mediated ligand binding
eventOf	[Pathway:R-DRE-190322] FGFR4 ligand binding and activation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-1307955] FGFR4 binds HS:KLB:FGF19 - Danio rerio [Reaction:R-DRE-1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 - Danio rerio
inferredFrom	[Pathway:R-HSA-1307965] betaKlotho-mediated ligand binding - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	betaKlotho-mediated ligand binding
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-1307965
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-190322] FGFR4 ligand binding and activation
(inferredTo)	[Pathway:R-HSA-1307965] betaKlotho-mediated ligand binding

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