Reactome | mRNA Cleaved by SMG6 [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10858334
displayName	mRNA Cleaved by SMG6 [cytosol]
hasComponent	[OtherEntity:R-ALL-927738] 3' Fragment of Cleaved mRNA [cytosol] [OtherEntity:R-ALL-927835] 5' Fragment of Cleaved mRNA [cytosol] [Complex:R-DME-162460] Cap Binding Complex (CBC) [cytosol] [EntityWithAccessionedSequence:R-DME-72584] eIF4G1 [cytosol] [GenomeEncodedEntity:R-DME-927838] Ghost homologue of SMG7 [cytosol] [DefinedSet:R-DME-156803-3] Homologues of PABPC1 [cytosol] [EntityWithAccessionedSequence:R-DME-927856] phospho-p-4S-UPF1 [cytosol] [Complex:R-DME-377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol] [EntityWithAccessionedSequence:R-DME-927867] Smg5 [cytosol] [EntityWithAccessionedSequence:R-DME-927851] Smg6 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-927845] mRNA Cleaved by SMG6 [cytosol] - Homo sapiens
maxDepth	3
name	mRNA Cleaved by SMG6
producedByEvent	[BlackBoxEvent:R-DME-927836] SMG6 hydrolyzes mRNA with premature termination codon - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-927845
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[BlackBoxEvent:R-DME-927836] SMG6 hydrolyzes mRNA with premature termination codon
(inferredTo)	[Complex:R-HSA-927845] mRNA Cleaved by SMG6 [cytosol]