Reactome | lwr [nucleoplasm]

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lwr [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10872335
displayName	lwr [nucleoplasm]
endCoordinate	158
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm] - Homo sapiens
maxDepth	1
name	lwr UBE2I Q7KNM2
producedByEvent	[Reaction:R-DME-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-6804468] PIAS1 SUMOylates SP3 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-6804468] PIAS1 SUMOylates SP3 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-6790454] SUMOylation of XPC - Drosophila melanogaster [Reaction:R-DME-4551679] RANBP2 SUMOylates RANBP2 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4551679] RANBP2 SUMOylates RANBP2 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4551679] RANBP2 SUMOylates RANBP2 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4551679] RANBP2 SUMOylates RANBP2 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4086059] SUMOylation of NPM1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4086059] SUMOylation of NPM1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-3108203] PRC1 SUMOylates CTBP1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-3108203] PRC1 SUMOylates CTBP1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4641350] PIAS4 SUMOylates TOP2A with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4641350] PIAS4 SUMOylates TOP2A with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4551738] SUMOylation of TDG with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4551738] SUMOylation of TDG with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-3000433] SUMOylation of PML with SUMO3 - Drosophila melanogaster [Reaction:R-DME-3000433] SUMOylation of PML with SUMO3 - Drosophila melanogaster [Reaction:R-DME-3000433] SUMOylation of PML with SUMO3 - Drosophila melanogaster [Reaction:R-DME-3000433] SUMOylation of PML with SUMO3 - Drosophila melanogaster [Reaction:R-DME-3000433] SUMOylation of PML with SUMO3 - Drosophila melanogaster [Reaction:R-DME-3000433] SUMOylation of PML with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4570553] SUMOylation of MDC1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4570553] SUMOylation of MDC1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4570463] CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4570463] CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-3000411] RANBP2 SUMOylates PML with SUMO2 - Drosophila melanogaster [Reaction:R-DME-3000411] RANBP2 SUMOylates PML with SUMO2 - Drosophila melanogaster [Reaction:R-DME-3000411] RANBP2 SUMOylates PML with SUMO2 - Drosophila melanogaster [Reaction:R-DME-3000411] RANBP2 SUMOylates PML with SUMO2 - Drosophila melanogaster [Reaction:R-DME-3000411] RANBP2 SUMOylates PML with SUMO2 - Drosophila melanogaster [Reaction:R-DME-3000411] RANBP2 SUMOylates PML with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4719413] PIAS2,3,4 SUMOylate RORA with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4719413] PIAS2,3,4 SUMOylate RORA with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4719423] PIAS2-2 SUMOylates THRA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4719423] PIAS2-2 SUMOylates THRA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4719423] PIAS2-2 SUMOylates THRA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4719423] PIAS2-2 SUMOylates THRA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4720446] HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4720446] HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4546385] PIAS1,3 SUMOylates NR5A1 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4546385] PIAS1,3 SUMOylates NR5A1 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4546385] PIAS1,3 SUMOylates NR5A1 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4546385] PIAS1,3 SUMOylates NR5A1 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4341072] SUMOylation of RARA with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4341072] SUMOylation of RARA with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4341072] SUMOylation of RARA with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4341072] SUMOylation of RARA with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4341072] SUMOylation of RARA with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4341072] SUMOylation of RARA with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4719448] PIAS1 SUMOylates THRB with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4719448] PIAS1 SUMOylates THRB with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4719448] PIAS1 SUMOylates THRB with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4719448] PIAS1 SUMOylates THRB with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4719448] PIAS1 SUMOylates THRB with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4719448] PIAS1 SUMOylates THRB with SUMO3 - Drosophila melanogaster [BlackBoxEvent:R-DME-4755524] SUMOylation of NR1I2 with SUMO3 - Drosophila melanogaster [BlackBoxEvent:R-DME-4755524] SUMOylation of NR1I2 with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4570489] SUMOylation of NOP58 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4570489] SUMOylation of NOP58 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4570489] SUMOylation of NOP58 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4570489] SUMOylation of NOP58 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4570499] CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4570499] CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4615900] PIAS1 SUMOylates SATB2 with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4615900] PIAS1 SUMOylates SATB2 with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4615900] PIAS1 SUMOylates SATB2 with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4615900] PIAS1 SUMOylates SATB2 with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4615987] RANBP2 SUMOylates HDAC4 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4615987] RANBP2 SUMOylates HDAC4 with SUMO2,3 - Drosophila melanogaster [Reaction:R-DME-4570485] SUMOylation of Histone H4 with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4570485] SUMOylation of Histone H4 with SUMO3 - Drosophila melanogaster [Reaction:R-DME-6804485] PIAS1 SUMOylates L3MBTL2 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-6804485] PIAS1 SUMOylates L3MBTL2 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-6804485] PIAS1 SUMOylates L3MBTL2 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-6804485] PIAS1 SUMOylates L3MBTL2 with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4546387] PIAS4 SUMOylates VDR with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4546387] PIAS4 SUMOylates VDR with SUMO2 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 - Drosophila melanogaster
referenceEntity	[ReferenceGeneProduct:uniprot:Q7KNM2] UniProt:Q7KNM2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:56210] Drosophila melanogaster
stId	R-DME-912481
startCoordinate	1

Referrals

(output)	[Reaction:R-DME-4551679] RANBP2 SUMOylates RANBP2 with SUMO2 [Reaction:R-DME-4086059] SUMOylation of NPM1 with SUMO2,3 [Reaction:R-DME-3108203] PRC1 SUMOylates CTBP1 with SUMO2,3 [Reaction:R-DME-4085372] PIAS1 SUMOylates SAFB with SUMO2,3 [Reaction:R-DME-4641350] PIAS4 SUMOylates TOP2A with SUMO2,3 [Reaction:R-DME-4551738] SUMOylation of TDG with SUMO2,3 [Reaction:R-DME-3000433] SUMOylation of PML with SUMO3 [Reaction:R-DME-4570553] SUMOylation of MDC1 with SUMO2,3 [Reaction:R-DME-4570463] CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 [Reaction:R-DME-4568914] SUMOylation of BLM with SUMO2,3 [Reaction:R-DME-3000411] RANBP2 SUMOylates PML with SUMO2 [Reaction:R-DME-4719413] PIAS2,3,4 SUMOylate RORA with SUMO2 [Reaction:R-DME-4720432] HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 [Reaction:R-DME-4719423] PIAS2-2 SUMOylates THRA with SUMO3 [Reaction:R-DME-4720446] HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 [Reaction:R-DME-4546385] PIAS1,3 SUMOylates NR5A1 with SUMO2 [Reaction:R-DME-4341072] SUMOylation of RARA with SUMO2 [Reaction:R-DME-4719448] PIAS1 SUMOylates THRB with SUMO3 [BlackBoxEvent:R-DME-4755524] SUMOylation of NR1I2 with SUMO3 [Reaction:R-DME-3465545] PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 [Reaction:R-DME-6804468] PIAS1 SUMOylates SP3 with SUMO2 [Reaction:R-DME-4570489] SUMOylation of NOP58 with SUMO2 [Reaction:R-DME-4570499] CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 [Reaction:R-DME-4615900] PIAS1 SUMOylates SATB2 with SUMO3 [Reaction:R-DME-4615839] PIAS1 SUMOylates SATB1 with SUMO2,3 [Reaction:R-DME-4615987] RANBP2 SUMOylates HDAC4 with SUMO2,3 [Reaction:R-DME-4570485] SUMOylation of Histone H4 with SUMO3 [Reaction:R-DME-6804485] PIAS1 SUMOylates L3MBTL2 with SUMO2 [Reaction:R-DME-4546387] PIAS4 SUMOylates VDR with SUMO2 [Reaction:R-DME-4755536] PIAS3 SUMOylates RELA with SUMO3 [Reaction:R-DME-6790454] SUMOylation of XPC
(activeUnit)	[CatalystActivity:10874973] SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] [CatalystActivity:10875195] SUMO transferase activity of SUMO2:UBE2I [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]

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