Reactome | PIAS4 SUMOylates TOP2A with SUMO2,3

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PIAS4 SUMOylates TOP2A with SUMO2,3 Show undefined attributes

catalystActivity	[CatalystActivity:10875296] SUMO transferase activity of PIAS4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10875501
displayName	PIAS4 SUMOylates TOP2A with SUMO2,3
eventOf	[Pathway:R-DME-4615885] SUMOylation of DNA replication proteins - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:4162] protein sumoylation
inferredFrom	[Reaction:R-HSA-4641350] PIAS4 SUMOylates TOP2A with SUMO2,3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-1362276] TOP2A [nucleoplasm] 2 × [DefinedSet:R-DME-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PIAS4 SUMOylates TOP2A with SUMO2,3
output	2 × [EntityWithAccessionedSequence:R-DME-912481] lwr [nucleoplasm] [EntityWithAccessionedSequence:R-DME-4641298] polySUMO2,3-TOP2A [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-4641350
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-4615885] SUMOylation of DNA replication proteins
(inferredTo)	[Reaction:R-HSA-4641350] PIAS4 SUMOylates TOP2A with SUMO2,3

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