Reactome | SLC35B2,3 exchange cytosolic PAPS with Golgi PAP

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SLC35B2,3 exchange cytosolic PAPS with Golgi PAP Show undefined attributes

catalystActivity	[CatalystActivity:10857237] 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity of SLC35B2,3 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10857239
displayName	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP
eventOf	[Pathway:R-DME-727802] Transport of nucleotide sugars - Drosophila melanogaster [Pathway:R-DME-174362] Transport and metabolism of PAPS - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-9940718] CHST10 sulfates matriglycan chain - Drosophila melanogaster [Reaction:R-DME-6786012] CHST4 transfers SO4(2-) from PAPS to Core 2 mucins - Drosophila melanogaster [Reaction:R-DME-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - Drosophila melanogaster [Reaction:R-DME-2022061] Dermatan sulfate can be further sulfated on position 2 of iduronate - Drosophila melanogaster [Reaction:R-DME-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Drosophila melanogaster [Reaction:R-DME-2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate - Drosophila melanogaster [Reaction:R-DME-2046175] CHST1 transfers sulfate to Gal on keratan chain - Drosophila melanogaster [Reaction:R-DME-1971483] CHST11,12,13,9 transfer sulfate to (4-)GalNAc - Drosophila melanogaster [Reaction:R-DME-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate - Drosophila melanogaster [Reaction:R-DME-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Drosophila melanogaster [Reaction:R-DME-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) - Drosophila melanogaster [Reaction:R-DME-2018682] CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains - Drosophila melanogaster
goBiologicalProcess	[GO_BiologicalProcess:5263389] 5'-adenylyl sulfate transmembrane transport
inferredFrom	[Reaction:R-HSA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Homo sapiens
input	[SimpleEntity:R-ALL-742343] PAP [Golgi lumen] [SimpleEntity:R-ALL-158471] PAPS [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP
output	[SimpleEntity:R-ALL-158466] PAP [cytosol] [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
precedingEvent	[Reaction:R-DME-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-741449
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DME-9940718] CHST10 sulfates matriglycan chain [Reaction:R-DME-6786012] CHST4 transfers SO4(2-) from PAPS to Core 2 mucins [Reaction:R-DME-2046175] CHST1 transfers sulfate to Gal on keratan chain [Reaction:R-DME-2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain [Reaction:R-DME-2018682] CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains [Reaction:R-DME-2022061] Dermatan sulfate can be further sulfated on position 2 of iduronate [Reaction:R-DME-1971483] CHST11,12,13,9 transfer sulfate to (4-)GalNAc [Reaction:R-DME-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin [Reaction:R-DME-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate [Reaction:R-DME-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate [Reaction:R-DME-2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate [Reaction:R-DME-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
(hasEvent)	[Pathway:R-DME-727802] Transport of nucleotide sugars [Pathway:R-DME-174362] Transport and metabolism of PAPS
(inferredTo)	[Reaction:R-HSA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP

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