Reactome | RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3

Schema > Reaction > Entries

RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10879306
displayName	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
eventOf	[Pathway:R-DME-5625740] RHO GTPases activate PKNs - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5623622] RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 - Homo sapiens
input	[CandidateSet:R-DME-5623626] PKN1-3 [cytosol] [Complex:R-DME-5624294] RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
output	[Complex:R-DME-5623624] RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5623622
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5625740] RHO GTPases activate PKNs
(precedingEvent)	[Reaction:R-DME-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
(inferredTo)	[Reaction:R-HSA-5623622] RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3

Cite Us!