Reactome | Detoxification of Reactive Oxygen Species

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Detoxification of Reactive Oxygen Species Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:984] extracellular region [Compartment:70616] mitochondrial inner membrane [Compartment:17927] mitochondrial intermembrane space [Compartment:5460] mitochondrial matrix [Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910746
displayName	Detoxification of Reactive Oxygen Species
eventOf	[Pathway:R-DME-9711123] Cellular response to chemical stress - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:376615] cellular response to oxidative stress
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-3697860] SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ - Drosophila melanogaster [Reaction:R-DME-8951723] 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates - Drosophila melanogaster [Reaction:R-DME-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 - Drosophila melanogaster [Reaction:R-DME-6807557] NOX4, NOX5 reduce O2 to O2.- - Drosophila melanogaster [Reaction:R-DME-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Drosophila melanogaster [Reaction:R-DME-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Drosophila melanogaster [Reaction:R-DME-3299680] SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) - Drosophila melanogaster [Reaction:R-DME-76031] 2 H2O2 => O2 + 2 H2O - Drosophila melanogaster [Reaction:R-DME-3322995] PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O - Drosophila melanogaster [Reaction:R-DME-3341294] Superoxide reduces cytochrome c - Drosophila melanogaster [Reaction:R-DME-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Drosophila melanogaster [Reaction:R-DME-73646] Regeneration of active (reduced) Thioredoxin - Drosophila melanogaster [Reaction:R-DME-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN - Drosophila melanogaster [Reaction:R-DME-3697894] PRDX5 reduces peroxynitrite to nitrite using TXN2 - Drosophila melanogaster [Reaction:R-DME-5696197] NUDT2 hydrolyses GP4G to GTP, GMP - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Detoxification of Reactive Oxygen Species
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-3299685
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9711123] Cellular response to chemical stress
(hasEncapsulatedEvent)	[Pathway:R-DME-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Pathway:R-DME-5628897] TP53 Regulates Metabolic Genes
(inferredTo)	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species

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