Reactome | p-T,2S-SMAD2,3:SMAD4 [nucleoplasm]

Schema > DefinedSet > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DME-2176504] Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-2176491] NEDD4L binds phosphorylated linker region of SMAD2/3 - Drosophila melanogaster [Reaction:R-DME-2179274] SMURF2 binds SMAD3 phosphorylated in the linker region - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10870523
displayName	p-T,2S-SMAD2,3:SMAD4 [nucleoplasm]
hasMember	[Complex:R-DME-9736936] p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] - Drosophila melanogaster [Complex:R-DME-9736938] p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] - Drosophila melanogaster [Complex:R-DME-9736939] p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] - Drosophila melanogaster
inDisease	false
inferredFrom	[DefinedSet:R-HSA-2176487] p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] - Homo sapiens
maxDepth	3
name	p-T,2S-SMAD2,3:SMAD4
producedByEvent	[Reaction:R-DME-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Drosophila melanogaster
schemaClass	DefinedSet
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2176487

(hasComponent)	[Complex:R-DME-2176504] Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] [Complex:R-DME-2176495] p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] [Complex:R-DME-2179277] p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm]
(input)	[Reaction:R-DME-2176491] NEDD4L binds phosphorylated linker region of SMAD2/3 [Reaction:R-DME-2179274] SMURF2 binds SMAD3 phosphorylated in the linker region
(output)	[Reaction:R-DME-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
(inferredTo)	[DefinedSet:R-HSA-2176487] p-T,2S-SMAD2,3:SMAD4 [nucleoplasm]