Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP
Show undefined attributes
Go to Details
authored
[InstanceEdit:386954] Williams, MG, 2006-11-02 16:49:12
category
binding
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:205673] Williams, MG, 2006-11-03 15:40:44
dbId
209255
displayName
UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP
edited
[InstanceEdit:205673] Williams, MG, 2006-11-03 15:40:44
eventOf
[Pathway:R-DME-209209] Formation of the activated receptor complex - Drosophila melanogaster
figure
[Figure:208794] /figures/ADrosJAKSTAT03.jpg
followingEvent
[Reaction:R-DME-209336] Activated HOP is autophosphorylated and/or transphosphorylated - Drosophila melanogaster
input
[Complex:R-DME-206971] HOP:DOME:DOME:HOP [plasma membrane]
[DefinedSet:R-DME-206555] UPD [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:208179] mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family
[LiteratureReference:208055] Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand
[LiteratureReference:208064] A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation
[LiteratureReference:208109] Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP
output
[Complex:R-DME-206753] HOP:DOME:UPD:DOME:HOP [plasma membrane]
precedingEvent
[Reaction:R-DME-209231] DOME:HOP complex forms a dimer at the plasma membrane - Drosophila melanogaster
releaseDate
2009-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:386947] Perrimon, N, 2008-01-16 11:04:04
schemaClass
Reaction
species
[Species:56210] Drosophila melanogaster
stId
R-DME-209255
summation
[Summation:206510] The UPD (OS, UPD2, UPD3) family of ligands bind to the DOME:...
Referrals
(hasEvent)
[Pathway:R-DME-209209] Formation of the activated receptor complex
(precedingEvent)
[Reaction:R-DME-209336] Activated HOP is autophosphorylated and/or transphosphorylated
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text