UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP

Stable Identifier
R-DME-209255
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP
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The UPD (OS, UPD2, UPD3) family of ligands bind to the DOME:HOP dimer complex. Ligand binding suggests an induced conformational change in the DOME receptor that brings the HOP proteins, bound to the intracellular domains, closer together. The HOP tyrosine kinase is now activated.
Literature References
PubMed ID Title Journal Year
12967563 Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury

Agaisse, H, Petersen, UM, Boutros, M, Mathey-Prevot, B, Perrimon, N

Dev Cell 2003
16277982 Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand

Hombria, JC, Brown, S, Hader, S, Zeidler, MP

Dev Biol 2005
15925495 A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation

Gilbert, MM, Weaver, BK, Gergen, JP, Reich, NC

Mech Dev 2005
11825879 mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family

Chen, HW, Chen, X, Oh, SW, Marinissen, MJ, Gutkind, JS, Hou, SX

Genes Dev 2002
Participants
Input
Output
Participates
as an event of
Authored
Williams, MG  (2006-11-02)
Reviewed
Perrimon, N  (2008-01-16)
Created
Williams, MG  (2006-11-03)
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