Reactome | DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)

Stable Identifier

R-DME-209226

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

General

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The E3 ubiquitin ligases Neuralized (NEUR) or Mind Bomb 1 (MIB) ubiquitinate the Notch ligands Delta/Serrate (DL/SER).

Literature References

PubMed ID	Title	Journal	Year
16093323	The interplay between DSL proteins and ubiquitin ligases in Notch signaling Pitsouli, C, Delidakis, C	Development	2005
15760269	Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila Le Borgne, R, Remaud, S, Hamel, S, Schweisguth, F	PLoS Biol	2005
11740940	Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta Lai, EC, Deblandre, GA, Kintner, C, Rubin, GM	Dev Cell	2001
15829515	The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Lai, EC, Roegiers, F, Qin, X, Jan, YN, Rubin, GM	Development	2005