Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR

Stable Identifier
R-DME-209120
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated Arrow (ARR) is recognised by Axin (AXN) which binds to it along with the rest of the 'destruction complex'. Dishevelled (DSH) is recruited to the cytoplasmic part of Frizzled (FZ/FZ2) and additionally forms an interaction with AXN. There is conjecture whether DSH first binds to AXN, helping to recruit it to the membrane, while the 'destruction complex' is free in the cytoplasm.

Literature References
PubMed ID Title Journal Year
10846164 Signaling specificity by Frizzled receptors in Drosophila

Boutros, M, Mihaly, J, Bouwmeester, T, Mlodzik, M

Science 2000
11336703 Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

Mao, J, Wang, J, Liu, B, Pan, W, Farr GH, 3rd, Flynn, C, Yuan, H, Takada, S, Kimelman, D, Li, L, Wu, D

Mol Cell 2001
12781135 A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling

Cliffe, A, Hamada, F, Bienz, M

Curr Biol 2003
15459103 Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Cong, F, Schweizer, L, Varmus, H

Development 2004
12636921 Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

Tolwinski, NS, Wehrli, M, Rives, A, Erdeniz, N, DiNardo, S, Wieschaus, E

Dev Cell 2003
14636582 Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

Wong, HC, Bourdelas, A, Krauss, A, Lee, HJ, Shao, Y, Wu, D, Mlodzik, M, Shi, DL, Zheng, J

Mol Cell 2003
14731402 A mechanism for Wnt coreceptor activation

Tamai, K, Zeng, X, Liu, C, Zhang, X, Harada, Y, Chang, Z, He, X

Mol Cell 2004
Participants
Participant Of
Authored
Reviewed
Created