Destabilisation and degradation of AXN in the 'destruction complex'

Stable Identifier
R-DME-209075
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
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Axin (AXN) is now destabilised and is degraded by an unknown mechanism, possibly by a similar ubiquitin-mediated proteolysis responsible for cytoplasmic Armadillo (ARM) degradation.

Literature References
PubMed ID Title Journal Year
10196136 Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

Yamamoto, H, Kishida, S, Kishida, M, Ikeda, S, Takada, S, Kikuchi, A

J Biol Chem 1999
12636921 Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

Tolwinski, NS, Wehrli, M, Rives, A, Erdeniz, N, DiNardo, S, Wieschaus, E

Dev Cell 2003
10421629 Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

Willert, K, Shibamoto, S, Nusse, R

Genes Dev 1999
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