Reactome | OSBPs transport 25OH-CHOL from ER membrane to plasma membrane

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OSBPs transport 25OH-CHOL from ER membrane to plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10895486] sterol transfer activity of OSBPs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10895488
displayName	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane
eventOf	[Pathway:R-DME-192105] Synthesis of bile acids and bile salts - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-8867667] OSBPs transport 25OH-CHOL from ER membrane to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-8868399] 25OH-CHOL [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	OSBPs transport 25OH-CHOL from ER membrane to plasma membrane
output	[SimpleEntity:R-ALL-8868400] 25OH-CHOL [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8867667
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-192105] Synthesis of bile acids and bile salts
(precedingEvent)	[Reaction:R-DME-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane
(inferredTo)	[Reaction:R-HSA-8867667] OSBPs transport 25OH-CHOL from ER membrane to plasma membrane

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