Reactome | mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane]

Schema > Complex > Entries

compartment	[Compartment:17938] lysosomal membrane
consumedByEvent	[Reaction:R-DME-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10839297
displayName	mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane]
hasComponent	[Complex:R-DME-165678] Active mTORC1 complex [lysosomal membrane] [EntityWithAccessionedSequence:R-DME-200155] PRAS40 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5672831] mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] - Homo sapiens
maxDepth	9
name	mTORC1:RHEB:GTP:AKT1S1
negativelyRegulates	[NegativeRegulation:10839307] Negative regulation by 'mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane]'
producedByEvent	[Reaction:R-DME-5672843] AKT1S1 (PRAS40) binds mTORC1 - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5672831
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[NegativeRegulation:10839307] Negative regulation by 'mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane]'
(input)	[Reaction:R-DME-377186] Activated AKT phosphorylates AKT1S1 (PRAS40)
(output)	[Reaction:R-DME-5672843] AKT1S1 (PRAS40) binds mTORC1
(inferredTo)	[Complex:R-HSA-5672831] mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane]

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