Reactome | AKT1 phosphorylates eNOS

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AKT1 phosphorylates eNOS Show undefined attributes

catalystActivity	[CatalystActivity:10843926] protein serine/threonine kinase activity of eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10843928
displayName	AKT1 phosphorylates eNOS
eventOf	[Pathway:R-DME-203615] eNOS activation - Drosophila melanogaster [Pathway:R-DME-5218920] VEGFR2 mediated vascular permeability - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-202111] AKT1 phosphorylates eNOS - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DME-202113] eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	AKT1 phosphorylates eNOS ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-DME-202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
precedingEvent	[Reaction:R-DME-202137] AKT1 binds eNOS complex via HSP90 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-202111
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5218920] VEGFR2 mediated vascular permeability [Pathway:R-DME-203615] eNOS activation
(precedingEvent)	[Reaction:R-DME-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
(inferredTo)	[Reaction:R-HSA-202111] AKT1 phosphorylates eNOS

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