Reactome | GCH1 reduces GTP to dihydroneopterin triphosphate

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GCH1 reduces GTP to dihydroneopterin triphosphate Show undefined attributes

catalystActivity	[CatalystActivity:10692594] GTP cyclohydrolase I activity of GCH1 decamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10692596
displayName	GCH1 reduces GTP to dihydroneopterin triphosphate
eventOf	[Pathway:R-DME-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-1474146] GCH1 reduces GTP to dihydroneopterin triphosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
name	GCH1 reduces GTP to dihydroneopterin triphosphate
output	[SimpleEntity:R-ALL-1474124] DHNTP [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol]
regulatedBy	[NegativeRegulation:R-HSA-1474156] Negative regulation by 'BH4 [cytosol]' [PositiveRegulation:R-HSA-1474173] Positive regulation by 'L-Phe [cytosol]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1474146
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
(precedingEvent)	[Reaction:R-DME-1474184] DHNTP is dephosphorylated by PTPS to PTHP
(inferredTo)	[Reaction:R-HSA-1474146] GCH1 reduces GTP to dihydroneopterin triphosphate