Reactome | NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-1168617] NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10860642
displayName	NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol]
hasMember	[Complex:R-DME-1168600] NF-KappaB p50:p50:p-IKBA [cytosol] - Drosophila melanogaster [Complex:R-DME-1168612] NF-kappaB p50:c-Rel:p-IKB [cytosol] - Drosophila melanogaster [Complex:R-DME-5607671] p-S32,36-IkB-alpha:NF-kB complex [cytosol] - Drosophila melanogaster [Complex:R-DME-1168594] NF-kappaB p65:p65:p-IKB [cytosol] - Drosophila melanogaster
inDisease	false
inferredFrom	[DefinedSet:R-HSA-1168588] NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] - Homo sapiens
maxDepth	5
name	NF-kappa-B p50,p65,c-Rel:p-IKB
producedByEvent	[Reaction:R-DME-1168638] Activated IKK phosphorylates I-kappaB - Drosophila melanogaster
schemaClass	DefinedSet
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1168588

(input)	[Reaction:R-DME-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB
(output)	[Reaction:R-DME-1168638] Activated IKK phosphorylates I-kappaB
(hasComponent)	[Complex:R-DME-1168617] NF-kappaB:p-IkB:SCF-betaTrCP [cytosol]
(inferredTo)	[DefinedSet:R-HSA-1168588] NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol]

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