Reactome | p-S32,36-IkB-alpha:NF-kB complex [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
consumedByEvent	[BlackBoxEvent:R-DME-5607728] beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10844032
displayName	p-S32,36-IkB-alpha:NF-kB complex [cytosol]
hasComponent	[Complex:R-DME-168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol] [EntityWithAccessionedSequence:R-DME-177677] phospho-cact [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-1168611] NF-kappaB p50:p65:p-IKB [cytosol] - Homo sapiens [Complex:R-HSA-5607671] p-S32,36-IkB-alpha:NF-kB complex [cytosol] - Homo sapiens
maxDepth	4
memberOf	[DefinedSet:R-DME-1168588] NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] - Drosophila melanogaster
name	p-S32,36-IkB-alpha:NF-kB complex
producedByEvent	[Reaction:R-DME-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5607671
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasMember)	[DefinedSet:R-DME-1168588] NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol]
(inferredTo)	[Complex:R-HSA-1168611] NF-kappaB p50:p65:p-IKB [cytosol] [Complex:R-HSA-5607671] p-S32,36-IkB-alpha:NF-kB complex [cytosol]
(input)	[BlackBoxEvent:R-DME-5607728] beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex
(output)	[Reaction:R-DME-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB