Reactome | Activation of DAkt1 by DPDK1

Schema > Reaction > Entries

Activation of DAkt1 by DPDK1 Show undefined attributes

authored	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
catalystActivity	[CatalystActivity:110467] 3-phosphoinositide-dependent protein kinase activity of PK61C [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
dbId	110468
displayName	Activation of DAkt1 by DPDK1
edited	[InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
eventOf	[Pathway:R-DME-110478] Insulin signaling pathway - Drosophila melanogaster
followingEvent	[Reaction:R-DME-110475] DAkt1-mediated phosphorylation inactivates DFOXO - Drosophila melanogaster [Reaction:R-DME-169828] Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex - Drosophila melanogaster
goBiologicalProcess	[GO_BiologicalProcess:24738] positive regulation of cell size
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DME-110452] DAkt1:PIP3 complex [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:110469] PDK1 regulates growth through Akt and S6K in Drosophila. [LiteratureReference:110470] 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of DAkt1 by DPDK1
output	[EntityWithAccessionedSequence:R-DME-110466] Activated DAkt1 [cytosol] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-38117] PIP3 [plasma membrane]
precedingEvent	[Reaction:R-DME-110463] Increased PIP3 levels recruit DAkt1 to the membrane - Drosophila melanogaster
releaseDate	2016-01-17
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-110468
summation	[Summation:110471] DPDK1 (a phosphoinositide-dependant protein kinase) controls...

Referrals

(precedingEvent)	[Reaction:R-DME-110475] DAkt1-mediated phosphorylation inactivates DFOXO [Reaction:R-DME-169828] Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex
(hasEvent)	[Pathway:R-DME-110478] Insulin signaling pathway

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