Activation of DAkt1 by DPDK1

Stable Identifier
R-DME-110468
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of DAkt1 by DPDK1
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DPDK1 (a phosphoinositide-dependant protein kinase) controls cellular and organism growth through two effector pathways by activating DAkt and DS6K (S6 kinase). Phosphorylation of the residues Thr308 and Ser473 by DPDK1 (and another downstream kinase?) relieves intermolecular inhibition, allowing the activated DAkt to dissociate from PIP3 and modify its target, DFOXO.
Literature References
PubMed ID Title Journal Year
9368760 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi, DR, Deak, M, Casamayor, A, Caudwell, FB, Morrice, N, Norman, DG, Gaffney, P, Reese, CB, MacDougall, CN, Harbison, D, Ashworth, A, Bownes, M

Curr Biol 1998
11752451 PDK1 regulates growth through Akt and S6K in Drosophila.

Rintelen, F, Stocker, H, Thomas, G, Hafen, E

Proc Natl Acad Sci U S A 2001
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of cell size (0045793)
Catalyst Activity

3-phosphoinositide-dependent protein kinase activity of PK61C [cytosol]

Physical Entity
PK61C [cytosol] (Drosophila melanogaster)
Activity
3-phosphoinositide-dependent protein kinase activity (GO:0004676)
Authored
Jassal, B  (2004-02-11)
Created
Jassal, B  (2004-02-11)
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