DPDK1 (a phosphoinositide-dependant protein kinase) controls...

created [InstanceEdit:111280] Jassal, B, 2004-02-11 10:27:31
dbId 110471
displayName DPDK1 (a phosphoinositide-dependant protein kinase) controls...
modified [InstanceEdit:164720] Jassal, Bijay, 2005-06-16
schemaClass Summation
text DPDK1 (a phosphoinositide-dependant protein kinase) controls cellular and organism growth through two effector pathways by activating DAkt and DS6K (S6 kinase). Phosphorylation of the residues Thr308 and Ser473 by DPDK1 (and another downstream kinase?) relieves intermolecular inhibition, allowing the activated DAkt to dissociate from PIP3 and modify its target, DFOXO.
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