Reactome | phospho-p-T185,Y187-MAPK1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10853730] MAP kinase activity of p-T185,Y187-MAPK1 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-109855] p-T185,Y187 MAPK1 dimer [cytosol] - Drosophila melanogaster [Complex:R-DME-109855] p-T185,Y187 MAPK1 dimer [cytosol] - Drosophila melanogaster [Complex:R-DME-109854] p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] - Drosophila melanogaster [Complex:R-DME-445005] pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-445079] Phosphorylation of L1 by ERK - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10835990
displayName	phospho-p-T185,Y187-MAPK1 [cytosol]
endCoordinate	360
hasModifiedResidue	[ModifiedResidue:10835987] O-phospho-L-threonine at 185 (in Homo sapiens) [ModifiedResidue:10835988] O4'-phospho-L-tyrosine at 187 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-109853] p-T185,Y187-MAPK1 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-DME-169289] p-T,Y MAPKs [cytosol] - Drosophila melanogaster
name	phospho-p-T185,Y187-MAPK1 P40417
producedByEvent	[Reaction:R-DME-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Drosophila melanogaster
referenceEntity	[ReferenceGeneProduct:uniprot:P40417] UniProt:P40417
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:56210] Drosophila melanogaster
stId	R-DME-109853
startCoordinate	2

(input)	[Reaction:R-DME-445079] Phosphorylation of L1 by ERK
(physicalEntity)	[CatalystActivity:10853730] MAP kinase activity of p-T185,Y187-MAPK1 [cytosol]
(hasComponent)	[Complex:R-DME-445005] pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] [Complex:R-DME-109854] p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] [Complex:R-DME-109855] p-T185,Y187 MAPK1 dimer [cytosol]
(output)	[Reaction:R-DME-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
(hasMember)	[DefinedSet:R-DME-169289] p-T,Y MAPKs [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-109853] p-T185,Y187-MAPK1 [cytosol]

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