Reactome | RNA Polymerase II Promoter Opening: First Transition

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RNA Polymerase II Promoter Opening: First Transition Show undefined attributes

catalystActivity	[CatalystActivity:11001409] 3'-5' DNA helicase activity of TFIIH [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11001411
displayName	RNA Polymerase II Promoter Opening: First Transition
eventOf	[Pathway:R-DDI-76042] RNA Polymerase II Transcription Initiation And Promoter Clearance - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-75862] Fall Back to Closed Pre-initiation Complex - Dictyostelium discoideum [Reaction:R-DDI-75861] NTP Binds Active Site of RNA Polymerase II - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-75949] RNA Polymerase II Promoter Opening: First Transition - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-DDI-109635] pol II closed pre-initiation complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RNA Polymerase II Promoter Opening: First Transition
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-DDI-109876] pol II open pre-initiation complex [nucleoplasm]
precedingEvent	[Reaction:R-DDI-109639] Formation of the closed pre-initiation complex - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-75949
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-76042] RNA Polymerase II Transcription Initiation And Promoter Clearance
(precedingEvent)	[Reaction:R-DDI-75862] Fall Back to Closed Pre-initiation Complex [Reaction:R-DDI-75861] NTP Binds Active Site of RNA Polymerase II
(inferredTo)	[Reaction:R-HSA-75949] RNA Polymerase II Promoter Opening: First Transition

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