Reactome | MyD88 cascade initiated on plasma membrane

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MyD88 cascade initiated on plasma membrane Show undefined attributes

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049668
displayName	MyD88 cascade initiated on plasma membrane
eventOf	[Pathway:R-DDI-168176] Toll Like Receptor 5 (TLR5) Cascade - Dictyostelium discoideum [Pathway:R-DDI-168142] Toll Like Receptor 10 (TLR10) Cascade - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259820] MyD88-dependent toll-like receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DDI-937042] IRAK2 mediated activation of TAK1 complex - Dictyostelium discoideum [Pathway:R-DDI-445989] TAK1-dependent IKK and NF-kappa-B activation - Dictyostelium discoideum [Pathway:R-DDI-450294] MAP kinase activation - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	MyD88 cascade initiated on plasma membrane
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-975871
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-168142] Toll Like Receptor 10 (TLR10) Cascade [Pathway:R-DDI-168176] Toll Like Receptor 5 (TLR5) Cascade
(inferredTo)	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane

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