Reactome | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion

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Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049908
displayName	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
eventOf	[Pathway:R-DDI-400451] Free fatty acids regulate insulin secretion - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262055] positive regulation of insulin secretion
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-434316
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-400451] Free fatty acids regulate insulin secretion
(inferredTo)	[Pathway:R-HSA-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion

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