Reactome | CAK-mediated phosphorylation of Cyclin A:Cdk2

Schema > Reaction > Entries

CAK-mediated phosphorylation of Cyclin A:Cdk2 Show undefined attributes

catalystActivity	[CatalystActivity:11005081] protein serine/threonine kinase activity of CAK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11005083
displayName	CAK-mediated phosphorylation of Cyclin A:Cdk2
eventOf	[Pathway:R-DDI-69656] Cyclin A:Cdk2-associated events at S phase entry - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 - Dictyostelium discoideum [Reaction:R-DDI-187948] Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 - Dictyostelium discoideum [Reaction:R-DDI-188371] Association of Cyclin A:Cdk2 with Cdh1 - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-DDI-141608] CCNA:CDK2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CAK-mediated phosphorylation of Cyclin A:Cdk2
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-DDI-187952] CCNA:p-T160-CDK2 [nucleoplasm]
precedingEvent	[Reaction:R-DDI-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - Dictyostelium discoideum [Reaction:R-DDI-174273] Translocation of Cyclin A:Cdk2 complexes to the nucleus - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-187949
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DDI-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 [Reaction:R-DDI-187948] Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 [Reaction:R-DDI-188371] Association of Cyclin A:Cdk2 with Cdh1
(hasEvent)	[Pathway:R-DDI-69656] Cyclin A:Cdk2-associated events at S phase entry
(inferredTo)	[Reaction:R-HSA-187949] CAK-mediated phosphorylation of Cyclin A:Cdk2