Reactome | nsp15 hexamer [cytosol]

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nsp15 hexamer [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9694258] nsp15:RB1 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9694390] nsp15 binds RB1 - Homo sapiens [Reaction:R-HSA-9694539] nsp15 binds nsp8 - Homo sapiens
created	[InstanceEdit:9694660] Cook, Justin, 2020-07-07
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9694570
disease	[Disease:9683912] COVID-19
displayName	nsp15 hexamer [cytosol]
hasComponent	6 × [EntityWithAccessionedSequence:R-COV-9694335] pp1ab-nsp15 [cytosol]
inDisease	true
inferredFrom	[Complex:R-COV-9682715] nsp15 hexamer [cytosol] - Human SARS coronavirus
isChimeric	false
literatureReference	[LiteratureReference:9682714] The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein [LiteratureReference:9683204] Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15 [LiteratureReference:9683208] Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch [LiteratureReference:9683220] Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family [LiteratureReference:9683386] RNA recognition and cleavage by the SARS coronavirus endoribonuclease [LiteratureReference:9683389] Mutational analysis of the SARS virus Nsp15 endoribonuclease: identification of residues affecting hexamer formation
maxDepth	2
modified	[InstanceEdit:9696709] Orlic-Milacic, Marija, 2020-07-28
name	nsp15 hexamer
producedByEvent	[Reaction:R-HSA-9694436] nsp15 forms a hexamer - Homo sapiens
schemaClass	Complex
species	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
stId	R-COV-9694570
summation	[Summation:9694775] This COVID-19 Complex instance was generated via electronic inference from a curated CoV-1 (Human SARS coronavirus) Reactome instance. In Reactome, inference is the process used to automatically create orthologous Pathways, Reactions and PhysicalEntities from our expertly curated data (https://reactome.org/documentation/inferred-events).

Referrals

(input)	[Reaction:R-HSA-9694390] nsp15 binds RB1 [Reaction:R-HSA-9694539] nsp15 binds nsp8
(hasComponent)	[Complex:R-HSA-9694258] nsp15:RB1 [cytosol] [Complex:R-COV-9694740] nsp7:nsp8:nsp12:nsp14:nsp10:nsp13:nsp15 [cytosol]
(output)	[Reaction:R-HSA-9694436] nsp15 forms a hexamer
(inferredTo)	[Complex:R-COV-9682715] nsp15 hexamer [cytosol]

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