nsp15 hexamer [cytosol]

Stable Identifier
R-COV-9694570
Type
Complex
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
Locations in the PathwayBrowser
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General
This COVID-19 Complex instance was generated via electronic inference from a curated CoV-1 (Human SARS coronavirus) Reactome instance. In Reactome, inference is the process used to automatically create orthologous Pathways, Reactions and PhysicalEntities from our expertly curated data (https://reactome.org/documentation/inferred-events).
Literature References
PubMed ID Title Journal Year
16216269 Mutational analysis of the SARS virus Nsp15 endoribonuclease: identification of residues affecting hexamer formation

Dong, W, Holzenburg, A, Guarino, LA, Kao, C, Sun, J, Bhardwaj, K

J. Mol. Biol. 2005
17409150 Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch

Subramanian, V, Neuman, BW, Saikatendu, KS, Buchmeier, MJ, Joseph, JS, Kuhn, P, Stevens, RC

J. Virol. 2007
16828802 RNA recognition and cleavage by the SARS coronavirus endoribonuclease

Kao, CC, Guarino, LA, Holzenburg, A, Sun, J, Bhardwaj, K

J. Mol. Biol. 2006
22301153 The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein

Kao, CC, Liu, P, Bhardwaj, K, Leibowitz, JL

J. Virol. 2012
16882730 Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

Campanacci, V, Canard, B, Egloff, MP, Coutard, B, Ziebuhr, J, Ricagno, S, Cambillau, C, Ulferts, R, Nurizzo, D

Proc. Natl. Acad. Sci. U.S.A. 2006
18045871 Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15

Kao, CC, Alcantara, JM, Sacchettini, JC, Guarino, L, Bhardwaj, K, Yi, LL, Palaninathan, S

J. Biol. Chem. 2008
Participants
components
Participates
as an input of
as a component of
as an output of
Inferred From
nsp15 hexamer [cytosol] (Human SARS coronavirus)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
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