Reactome | pp1ab-nsp12 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-COV-9680807] nsp7:nsp8:nsp12 [cytosol] - Human SARS coronavirus
consumedByEvent	[Reaction:R-HSA-9680811] nsp12 binds nsp7 and nsp8 - Homo sapiens
created	[InstanceEdit:9678282] Orlic-Milacic, Marija, 2020-03-16
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9678280
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	pp1ab-nsp12 [cytosol]
endCoordinate	5301
inDisease	true
maxDepth	1
modified	[InstanceEdit:9689451] Orlic-Milacic, Marija, 2020-05-19
name	pp1ab-nsp12 RNA-directed RNA polymerase rep (4370 ? 5301) nsp12
producedByEvent	[Reaction:R-HSA-9684340] 3CLp cleaves pp1ab - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P0C6X7] UniProt:P0C6X7 rep
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:9678119] Human SARS coronavirus
stId	R-COV-9678280
startCoordinate	4370

(activeUnit)	[CatalystActivity:9713305] RNA-directed RNA polymerase activity of SARS-CoV-1 minus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] [CatalystActivity:9685678] RNA-directed RNA polymerase activity of SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] [CatalystActivity:9682251] RNA-directed RNA polymerase activity of SARS-CoV-1 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] [CatalystActivity:9681837] RNA-directed RNA polymerase activity of SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] [CatalystActivity:9682467] RNA-directed RNA polymerase activity of SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane]
(input)	[Reaction:R-HSA-9680811] nsp12 binds nsp7 and nsp8
(output)	[Reaction:R-HSA-9684340] 3CLp cleaves pp1ab
(hasComponent)	[Complex:R-COV-9680807] nsp7:nsp8:nsp12 [cytosol]

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